Association Between Poor Cognitive Functioning and Risk of Incident Parkinsonism: The Rotterdam Study.

ABSTRACT:

Importance

Cognitive dysfunction is a common feature among patients with parkinsonism, including Parkinson disease (PD). However, there is a scarcity of data on cognitive functioning before parkinsonism diagnosis, a stage at which patients may still respond to putative disease-modifying interventions.

Objective

To assess whether poor cognitive functioning is associated with an increased risk of parkinsonism.

Design, setting, and participants

Between January 8, 2002, and December 14, 2008, baseline cognitive function was assessed in 7386 participants of the Rotterdam Study who were free of parkinsonism and dementia. Four tests were administered (Stroop color word test, letter-digit substitution, verbal fluency, and word learning) and a global cognition score was derive

SUBMITTER: Darweesh SKL 

PROVIDER: S-EPMC5822187 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature