Alzheimer Disease Signature Neurodegeneration and APOE Genotype in Mild Cognitive Impairment With Suspected Non-Alzheimer Disease Pathophysiology.

ABSTRACT:

Importance

There are conflicting results claiming that Alzheimer disease signature neurodegeneration may be more, less, or similarly advanced in individuals with β-amyloid peptide (Aβ)-negative (Aβ-) suspected non-Alzheimer disease pathophysiology (SNAP) than in Aβ-positive (Aβ+) counterparts.

Objective

To examine patterns of neurodegeneration in individuals with SNAP compared with their Aβ+ counterparts.

Design, setting, and participants

A longitudinal cohort study was conducted among individuals with mild cognitive impairment (MCI) and cognitively normal individuals receiving care at Alzheimer's Disease Neuroimaging Initiative sites in the United States and Canada for a mean follow-up period of 30.5 months from August 1, 2005, to June 30, 2015. Several neurodegenera

SUBMITTER: Schreiber S 

PROVIDER: S-EPMC5822210 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature