Serum C-Reactive Protein as a Prognostic Biomarker in Amyotrophic Lateral Sclerosis.

ABSTRACT:

Importance

Various factors have been proposed as possible candidates associated with the prognosis of amyotrophic lateral sclerosis (ALS); however, there is still no consensus on which biomarkers are reliable prognostic factors. C-reactive protein (CRP) is a biomarker of the inflammatory response that shows significant prognostic value for several diseases.

Objective

To examine the prognostic significance of CRP in ALS.

Design, setting, and participants

Patients' serum CRP levels were evaluated from January 1, 2009, to June 30, 2015, in a large cohort of patients with ALS observed by an Italian tertiary multidisciplinary center. Results were replicated in an independent cohort obtained from a population-based registry of patients with ALS. A post hoc analysis was perf

SUBMITTER: Lunetta C 

PROVIDER: S-EPMC5822215 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature