Mineral trioxide aggregate improves healing response of periodontal tissue to injury in mice.

ABSTRACT:

Background and objective

Mineral trioxide aggregate (MTA) is a biomaterial used in endodontic procedures as it exerts beneficial effects on regenerative processes. In this study, we evaluate the effect of MTA on healing of periodontal ligament (PDL) and surrounding tissue, following injury, in a transgenic mouse model and on the differentiation of murine mesenchymal progenitor cells in vitro.

Material and methods

We used an inducible Cre-loxP in vivo fate mapping approach to examine the effects of MTA on the contributions of descendants of cells expressing the αSMA-CreERT2 transgene (SMA9⁺ ) to the PDL and alveolar bone after experimental injury to the root furcation on the maxillary first molars. Col2.3GFP was used as a marker to identify mature osteoblasts, ceme

SUBMITTER: Vidovic Zdrilic I 

PROVIDER: S-EPMC5822438 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature