Tumour radiosensitivity is associated with immune activation in solid tumours.

ABSTRACT:

Purpose

Our goal was to determine whether tumour radiosensitivity is associated with activation of the immune system across all tumour types as measured by two gene expression signatures (GESs).

Methods

We identified 10,240 genomically profiled distinct solid primary tumours with gene expression analysis available from an institutional de-identified database. Two separate GESs were included in the analysis, the radiosensitivity index (RSI) GES (a 10-gene GES as a measure of radiosensitivity) and the 12-chemokine (12-CK) signature (a 12-gene GES as a measure of immune activation). We tested whether the RSI and 12-CK were associated with each other across all tumour samples and, in an exploratory analysis, their prognostic significance in predicting distant metastasis-free sur

SUBMITTER: Strom T 

PROVIDER: S-EPMC5822441 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature