Genetic contributions to self-reported tiredness.

ABSTRACT: Self-reported tiredness and low energy, often called fatigue, are associated with poorer physical and mental health. Twin studies have indicated that this has a heritability between 6 and 50%. In the UK Biobank sample (N=108 976), we carried out a genome-wide association study (GWAS) of responses to the question, 'Over the last two weeks, how often have you felt tired or had little energy?' Univariate GCTA-GREML found that the proportion of variance explained by all common single-nucleotide polymorphisms for this tiredness question was 8.4% (s.e.=0.6%). GWAS identified one genome-wide significant hit (Affymetrix id 1:64178756_C_T; P=1.36 × 10^-11). Linkage disequilibrium score regression and polygenic profile score analyses were used to test for shared genetic aetiology between t

SUBMITTER: Deary V 

PROVIDER: S-EPMC5822465 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature