Early-life exposure to PM_2.5 and risk of acute asthma clinical encounters among children in Massachusetts: a case-crossover analysis.

ABSTRACT:

Background

Associations between ambient particulate matter < 2.5 μm (PM_2.5) and asthma morbidity have been suggested in previous epidemiologic studies but results are inconsistent for areas with lower PM_2.5 levels. We estimated the associations between early-life short-term PM_2.5 exposure and the risk of asthma or wheeze clinical encounters among Massachusetts children in the innovative Pregnancy to Early Life Longitudinal (PELL) cohort data linkage system.

Methods

We used a semi-bidirectional case-crossover study design with short-term exposure lags for asthma exacerbation using data from the PELL system. Cases included children up to 9 years of age who had a hospitalization, observational stay, or emergency department visit for asthma or wh

SUBMITTER: Khalili R 

PROVIDER: S-EPMC5822480 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature