Coupled changes in hippocampal structure and cognitive ability in later life.

ABSTRACT:

Introduction

The hippocampus plays an important role in cognitive abilities which often decline with advancing age.

Methods

In a longitudinal study of community-dwelling adults, we investigated whether there were coupled changes in hippocampal structure and verbal memory, working memory, and processing speed between the ages of 73 (N = 655) and 76 years (N = 469). Hippocampal structure was indexed by hippocampal volume, hippocampal volume as a percentage of intracranial volume (H_ICV), fractional anisotropy (FA), mean diffusivity (MD), and longitudinal relaxation time (T1).

Results

Mean levels of hippocampal volume, H_ICV, FA, T1, and all three cognitive abilities domains decreased, whereas MD increased, from age 73 to 76. At baseline, higher hippocampal

SUBMITTER: Anblagan D 

PROVIDER: S-EPMC5822578 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature