Propranolol can induce PTSD-like memory impairments in rats.

ABSTRACT:

Introduction

One hallmark symptom of post-traumatic stress disorder (PTSD) is an inability to restrict fear responses to the appropriate predictor. An infusion of glucocorticoids (GCs) after a high-intensity shock has been shown to induce PTSD-like memory impairments. In addition to GCs, noradrenergic signalling is also recognized as a key biomarker underlying PTSD symptomatology.

Methods

To explore the role of the noradrenergic system in PTSD-like memory impairments, in this study, various doses of the β-adrenoceptor antagonist propranolol were systemically or bilaterally injected into the dorsal hippocampus immediately after unpaired cue-shock contextual fear conditioning, and then the rats were tested 24 h later.

Results

Interestingly, we found that only low-dose p

SUBMITTER: Zhu RT 

PROVIDER: S-EPMC5822589 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature