Neurodegenerative disease biomarkers Aβ_1-40, Aβ_1-42, tau, and p-tau₁₈₁ in the vervet monkey cerebrospinal fluid: Relation to normal aging, genetic influences, and cerebral amyloid angiopathy.

ABSTRACT:

Background

The Caribbean vervet monkey (Chlorocebus aethiops sabaeus) is a potentially valuable animal model of neurodegenerative disease. However, the trajectory of aging in vervets and its relationship to human disease is incompletely understood.

Methods

To characterize biomarkers associated with neurodegeneration, we measured cerebrospinal fluid (CSF) concentrations of Aβ_1-40, Aβ_1-42, total tau, and p-tau₁₈₁ in 329 members of a multigenerational pedigree. Linkage and genome-wide association were used to elucidate a genetic contribution to these traits.

Results

Aβ_1-40 concentrations were significantly correlated with age, brain total surface area, and gray matter thickness. Levels of p-tau₁₈₁ were associa

SUBMITTER: Chen JA 

PROVIDER: S-EPMC5822592 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature