Expression profiling suggests microglial impairment in human immunodeficiency virus neuropathogenesis.

ABSTRACT:

Objective

CD16⁺ /CD163⁺ macrophages (MΦs) and microglia accumulate in the brains of patients with human immunodeficiency virus (HIV) encephalitis (HIVE), a neuropathological correlate of the most severe form of HIV-associated neurocognitive disorders, HIV-associated dementia. Recently, we found that some parenchymal microglia in brain of HIV⁺ subjects without encephalitis (HIV/noE) but with varying degrees of neurocognitive impairment express CD16 and CD163, even in the absence of detectable virus production. To further our understanding of microglial activation in HIV, we investigated expression of specific genes by profiling parenchymal microglia from archival brain tissue of patients with HIVE and HIV/noE, and HIV^- controls.

Methods

SUBMITTER: Ginsberg SD 

PROVIDER: S-EPMC5822676 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature