In trans hydrolysis of carrier protein-bound acyl intermediates by CitA during citrinin biosynthesis.

ABSTRACT: Polyketide synthases (PKSs) have several known editing mechanisms to ensure that non-productive intermediates are removed from the acyl carrier protein (ACP). We demonstrate that CitA, a putative hydrolase in the citrinin biosynthetic gene cluster, removes ACP-bound acyl intermediates. We propose that it serves an editing role in trans.

SUBMITTER: Storm PA 

PROVIDER: S-EPMC5822715 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature