Engineered modular biomaterial logic gates for environmentally triggered therapeutic delivery.

ABSTRACT: The successful transport of drug- and cell-based therapeutics to diseased sites represents a major barrier in the development of clinical therapies. Targeted delivery can be mediated through degradable biomaterial vehicles that utilize disease biomarkers to trigger payload release. Here, we report a modular chemical framework for imparting hydrogels with precise degradative responsiveness by using multiple environmental cues to trigger reactions that operate user-programmable Boolean logic. By specifying the molecular architecture and connectivity of orthogonal stimuli-labile moieties within material cross-linkers, we show selective control over gel dissolution and therapeutic delivery. To illustrate the versatility of this methodology, we synthesized 17 distinct stimuli-responsive materia

SUBMITTER: Badeau BA 

PROVIDER: S-EPMC5822735 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature