High serum levels of 8-OHdG are an independent predictor of post-stroke depression in Chinese stroke survivors.

ABSTRACT:

Purpose

Although previous studies have investigated oxidative stress biomarkers in association with depression in non-stroke subjects, the association between oxidative deoxyribonucleic acid damage and post-stroke depression (PSD) remains unelucidated.

Patients and methods

Two hundred forty-one first-ever ischemic stroke patients were consecutively recruited within the first 24 h of stroke onset and were followed up at 1 month. Serum 8-hydroxy-2'-deoxyguanosine (8-OHdG) and catalase (CAT) levels were measured within 24 h of admission using a commercially available enzyme-linked immunosorbent assay. The 17-item Hamilton Depression Scale was used to evaluate depressive symptoms. Diagnosis of PSD was made in line with the Diagnostic and Statistical Manual of Mental Disorders

SUBMITTER: Liu Z 

PROVIDER: S-EPMC5822852 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature