Ontology highlight
ABSTRACT:
SUBMITTER: Kramer NJ
PROVIDER: S-EPMC5823025 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20160801 6300
An expanded hexanucleotide repeat in C9orf72 causes amyotrophic lateral sclerosis and frontotemporal dementia (c9FTD/ALS). Therapeutics are being developed to target RNAs containing the expanded repeat sequence (GGGGCC); however, this approach is complicated by the presence of antisense strand transcription of expanded GGCCCC repeats. We found that targeting the transcription elongation factor Spt4 selectively decreased production of both sense and antisense expanded transcripts, as well as thei ...[more]