Polyaspartic acid-anchored mesoporous silica nanoparticles for pH-responsive doxorubicin release.

ABSTRACT:

Background

Nanotechnology-based drug delivery systems exhibit promising therapeutic efficacy in cancer chemotherapy. However, ideal nano drug carriers are supposed to be sufficiently internalized into cancer cells and then release therapeutic cargoes in response to certain intracellular stimuli, which has never been an easy task to achieve.

Objective

This study is to design mesoporous silica nanoparticles (MSNs)-based pH-responsive nano drug delivery system that is effectively internalized into cancer cells and then release drug in response to lysosomal/endosomal acidified environment.

Methods

We synthesized MSNs by sol-gel method. Doxorubicin (DOX) was encapsulated into the pores as a model drug. Polyaspartic acid (PAsA) was anchored on the surface of mesoporous MSNs

SUBMITTER: Hakeem A 

PROVIDER: S-EPMC5823071 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature