Latent-Profile Analysis Reveals Behavioral and Brain Correlates of Dopamine-Cognition Associations.

ABSTRACT: Evidence suggests that associations between the neurotransmitter dopamine and cognition are nonmonotonic and open to modulation by various other factors. The functional implications of a given level of dopamine may therefore differ from person to person. By applying latent-profile analysis to a large (n = 181) sample of adults aged 64-68 years, we probabilistically identified 3 subgroups that explain the multivariate associations between dopamine D2/3R availability (probed with 11C-raclopride-PET, in cortical, striatal, and hippocampal regions) and cognitive performance (episodic memory, working memory, and perceptual speed). Generally, greater receptor availability was associated with better cognitive performance. However, we discovered a subgroup of individuals for which high availabilit

SUBMITTER: Lovden M 

PROVIDER: S-EPMC5823239 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature