Effect of inorganic nitrate on exercise capacity in heart failure with preserved ejection fraction.

ABSTRACT:

Background

Inorganic nitrate (NO3(-)), abundant in certain vegetables, is converted to nitrite by bacteria in the oral cavity. Nitrite can be converted to nitric oxide in the setting of hypoxia. We tested the hypothesis that NO3(-) supplementation improves exercise capacity in heart failure with preserved ejection fraction via specific adaptations to exercise.

Methods and results

Seventeen subjects participated in this randomized, double-blind, crossover study comparing a single dose of NO3-rich beetroot juice (NO3(-), 12.9 mmol) with an identical nitrate-depleted placebo. Subjects performed supine-cycle maximal-effort cardiopulmonary exercise tests, with measurements of cardiac output and skeletal muscle oxygenation. We also assessed skeletal muscle oxidative function. Stud

SUBMITTER: Zamani P 

PROVIDER: S-EPMC5823250 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature