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Whole-Genome Analysis of Mycobacterium tuberculosis from Patients with Tuberculous Spondylitis, Russia.

ABSTRACT: Whole-genome analysis of Mycobacterium tuberculosis isolates collected in Russia (N = 71) from patients with tuberculous spondylitis supports a detailed characterization of pathogen strain distributions and drug resistance phenotype, plus distinguished occurrence and association of known resistance mutations. We identify known and novel genome determinants related to bacterial virulence, pathogenicity, and drug resistance.

SUBMITTER: Chernyaeva E 

PROVIDER: S-EPMC5823328 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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Whole-Genome Analysis of Mycobacterium tuberculosis from Patients with Tuberculous Spondylitis, Russia.

Chernyaeva Ekaterina E   Rotkevich Mikhail M   Krasheninnikova Ksenia K   Yurchenko Andrey A   Vyazovaya Anna A   Mokrousov Igor I   Solovieva Natalia N   Zhuravlev Viacheslav V   Yablonsky Piotr P   O'Brien Stephen J SJ  

Emerging infectious diseases 20180301 3

Whole-genome analysis of Mycobacterium tuberculosis isolates collected in Russia (N = 71) from patients with tuberculous spondylitis supports a detailed characterization of pathogen strain distributions and drug resistance phenotype, plus distinguished occurrence and association of known resistance mutations. We identify known and novel genome determinants related to bacterial virulence, pathogenicity, and drug resistance. ...[more]

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