Unique pharmacological properties of serotoninergic G-protein coupled receptors from cestodes.

ABSTRACT:

Background

Cestodes are a diverse group of parasites, some of them being agents of neglected diseases. In cestodes, little is known about the functional properties of G protein coupled receptors (GPCRs) which have proved to be highly druggable targets in other organisms. Notably, serotoninergic G-protein coupled receptors (5-HT GPCRs) play major roles in key functions like movement, development and reproduction in parasites.

Methodology/principal findings

Three 5-HT GPCRs from Echinococcus granulosus and Mesocestoides corti were cloned, sequenced, bioinformatically analyzed and functionally characterized. Multiple sequence alignment with other GPCRs showed the presence of seven transmembrane segments and conserved motifs but interesting differences were also observed. Phylog

SUBMITTER: Camicia F 

PROVIDER: S-EPMC5823469 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature