Differential expression of the angiotensin-(1-12)/chymase axis in human atrial tissue.

ABSTRACT:

Objective

Heart chymase rather than angiotensin converting enzyme has higher specificity for angiotensin (Ang) I conversion into Ang II in humans. A new pathway for direct cardiac Ang II generation has been revealed through the demonstration that Ang-(1-12) is cleaved by chymase to generate Ang II directly. We address here whether Ang-(1-12) and chymase gene expression and activity are detected in the atrial appendages of 44 patients (10 females) undergoing heart surgery for the correction of valvular heart disease, resistant atrial fibrillation or ischemic heart disease.

Methods and results

Immunoreactive Ang-(1-12) expression was 54% higher in left atrial compared with right atrial appendages. This was associated with higher abundance of left atrial appendage chymase gene

SUBMITTER: Nagata S 

PROVIDER: S-EPMC5823505 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature