Red blood cell storage in additive solution-7 preserves energy and redox metabolism: a metabolomics approach.

ABSTRACT:

Background

Storage and transfusion of red blood cells (RBCs) has a huge medical and economic impact. Routine storage practices can be ameliorated through the implementation of novel additive solutions (ASs) that tackle the accumulation of biochemical and morphologic lesion during routine cold liquid storage in the blood bank, such as the recently introduced alkaline solution AS-7. Here we hypothesize that AS-7 might exert its beneficial effects through metabolic modulation during routine storage.

Study design and methods

Apheresis RBCs were resuspended either in control AS-3 or experimental AS-7, before ultrahigh-performance liquid chromatography-mass spectrometry metabolomics analysis.

Results

Unambiguous assignment and relative quantitation was achieved for 229 meta

SUBMITTER: D'Alessandro A 

PROVIDER: S-EPMC5823509 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature