Hidden Complexity of Yeast Adaptation under Simple Evolutionary Conditions.

ABSTRACT: Few studies have "quantitatively" probed how adaptive mutations result in increased fitness. Even in simple microbial evolution experiments, with full knowledge of the underlying mutations and specific growth conditions, it is challenging to determine where within a growth-saturation cycle those fitness gains occur. A common implicit assumption is that most benefits derive from an increased exponential growth rate. Here, we instead show that, in batch serial transfer experiments, adaptive mutants' fitness gains can be dominated by benefits that are accrued in one growth cycle, but not realized until the next growth cycle. For thousands of evolved clones (most with only a single mutation), we systematically varied the lengths of fermentation, respiration, and stationary phases to assess how

SUBMITTER: Li Y 

PROVIDER: S-EPMC5823527 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature