The diagnostic role of DNA methylation in sporadic endometrial cancer: a systematic review and meta-analysis.

ABSTRACT:

Background

Although increasing numbers of methylated genes have been identified as biomarkers for endometrial cancer, the results have been inconsistent. We therefore carried out a systematic review and meta-analysis to evaluate the diagnostic accuracy of methylated genes as markers for sporadic endometrial cancer.

Results

A total of 22 studies including 1930 participants (sporadic endometrial cancer patients and normal individuals) met our eligibility criteria. The pooled sensitivity and specificity were 0.93 (95% confidence interval: 0.91-0.94) and 0.48 (95% confidence interval: 0.46-0.50), respectively. The area under the summary receiver operating characteristic curve was 0.8834. The presence of DNA methylation was significantly associated with lymph node metastasis of e

SUBMITTER: Fan Y 

PROVIDER: S-EPMC5823574 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature