The mutational landscape of MYCN, Lin28b and ALK^F1174L driven murine neuroblastoma mimics human disease.

ABSTRACT: Genetically engineered mouse models have proven to be essential tools for unraveling fundamental aspects of cancer biology and for testing novel therapeutic strategies. To optimally serve these goals, it is essential that the mouse model faithfully recapitulates the human disease. Recently, novel mouse models for neuroblastoma have been developed. Here, we report on the further genomic characterization through exome sequencing and DNA copy number analysis of four of the currently available murine neuroblastoma model systems (ALK, Th-MYCN, Dbh-MYCN and Lin28b). The murine tumors revealed a low number of genomic alterations - in keeping with human neuroblastoma - and a positive correlation of the number of genetic lesions with the time to onset of tumor formation

SUBMITTER: De Wilde B 

PROVIDER: S-EPMC5823580 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature