Polymorphisms in four microRNAs and risk of oral squamous cell cancer: a meta-analysis.

ABSTRACT:

Objectives

Single nucleotide polymorphisms in microRNAs (microRNA-196a2 rs11614913, microRNA-146a rs2910164, microRNA-149 rs2292832 and microRNA-499 rs3746444) have been inconsistently associated with risk for oral squamous cell cancer (OSCC). This meta-analysis aimed to assess the correlation between microRNA polymorphisms and susceptibility to OSCC.

Materials and methods

Free words were used to search for the relevant studies without language limitations in electronic databases including PubMed, Embase, Web of Science and SCOPUS through June 15, 2017. Odds ratios (ORs) were calculated to investigate the effects of microRNA polymorphisms on oral cancer risk.

Results

Eleven studies were included. Analysis under the recessive model of microRNA-146a (CC vs GG+CG) showed

SUBMITTER: Zeng J 

PROVIDER: S-EPMC5823596 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature