Differentially expressed microRNAs in lung adenocarcinoma invert effects of copy number aberrations of prognostic genes.

ABSTRACT: In many cancers, significantly down- or upregulated genes are found within chromosomal regions with DNA copy number alteration opposite to the expression changes. Generally, this paradox has been overlooked as noise, but can potentially be a consequence of interference of epigenetic regulatory mechanisms, including microRNA-mediated control of mRNA levels. To explore potential associations between microRNAs and paradoxes in non-small-cell lung cancer (NSCLC) we curated and analyzed lung adenocarcinoma (LUAD) data, comprising gene expressions, copy number aberrations (CNAs) and microRNA expressions. We integrated data from 1,062 tumor samples and 241 normal lung samples, including newly-generated array comparative genomic hybridization (aCGH) data from 63 LUAD samples. We identified 85 "par

SUBMITTER: Tokar T 

PROVIDER: S-EPMC5823624 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature