Efficacy and safety of Zhibitai in combination with atorvastatin for lipid lowering in patients with coronary heart disease.

ABSTRACT:

Background

Zhibitai, a natural lipid-lowering Chinese medicine, is well tolerated in patients and has low incidence of adverse events. In this study, we evaluated the efficacy, safety, and side effects of Zhibitai in combination with low dose Atorvastatin compared to high dose Atorvastatin in patients with coronary heart disease or at high risk of coronary heart disease.

Methods

This was a randomized, double-blind, multi-center clinical trial on 720 patients with coronary heart disease or at high risk of coronary heart disease. The patients were randomly assigned to a Zhibitai-Atorvastatin group (480 mg Zhibitai twice daily plus 10 mg atorvastatin once daily) or Monotherapy group (40 mg Atorvastatin once daily). Blood samples were obtained at baseline, week 4, and week 8 aft

SUBMITTER: Xu D 

PROVIDER: S-EPMC5823641 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature