Comparison of Immuno-PET of CD138 and PET imaging with ⁶⁴CuCl₂ and ¹⁸F-FDG in a preclinical syngeneic model of multiple myeloma.

ABSTRACT:

Purpose

Although recent data from the literature suggest that PET imaging with [18]-Fluorodeoxyglucose (¹⁸F-FDG) is a promising technique in multiple myeloma (MM), the development of other radiopharmaceuticals seems relevant. CD138 is currently used as a standard marker in many laboratories for the identification and purification of myeloma cells, and could be used in phenotype tumor imaging. In this study, we evaluated a ⁶⁴Cu-labeled anti-CD138 murine antibody (⁶⁴Cu-TE2A-9E7.4) and a metabolic tracer (⁶⁴CuCl₂) for PET imaging in a MM syngeneic mouse model.

Experimental design and results

⁶⁴Cu-TE2A-9E7.4 antibody and ⁶⁴CuCl2 were evaluated via PET imaging and biodistribution studies in C57BL / KaLwR

SUBMITTER: Bailly C 

PROVIDER: S-EPMC5823645 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature