Nicotine-induced activation of caudate and anterior cingulate cortex in response to errors in schizophrenia.

ABSTRACT:

Background

Nicotine improves attention and processing speed in individuals with schizophrenia. Few studies have investigated the effects of nicotine on cognitive control. Prior functional magnetic resonance imaging (fMRI) research demonstrates blunted activation of dorsal anterior cingulate cortex (dACC) and rostral anterior cingulate cortex (rACC) in response to error and decreased post-error slowing in schizophrenia.

Methods

Participants with schizophrenia (n = 13) and healthy controls (n = 12) participated in a randomized, placebo-controlled, crossover study of the effects of transdermal nicotine on cognitive control. For each drug condition, participants underwent fMRI while performing the stop signal task where participants attempt to inhibit prepotent responses to "go

SUBMITTER: Moran LV 

PROVIDER: S-EPMC5823729 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature