Predicting the bending properties of long bones: Insights from an experimental mouse model.

ABSTRACT:

Objectives

Analyses of bone cross-sectional geometry are frequently used by anthropologists and paleontologists to infer the loading histories of past populations. To address some underlying assumptions, we investigated the relative roles of genetics and exercise on bone cross-sectional geometry and bending mechanics in three mouse strains: high bone density (C3H/He), low bone density (C57BL/6), and a high-runner strain homozygous for the Myh4^Minimsc allele (MM).

Methods and materials

Weanlings of each strain were divided into exercise (wheel) or control (sedentary) treatment groups for a 7-week experimental period. Morphometrics of the femoral mid-diaphysis and mechanical testing were used to assess both theoretical and ex vivo bending mechanics.

Results

A

SUBMITTER: Peacock SJ 

PROVIDER: S-EPMC5823733 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature