The gp130 Cytokine Interleukin-11 Regulates Engraftment of Vav1^-/- Hematopoietic Stem and Progenitor Cells in Lethally Irradiated Recipients.

ABSTRACT: During bone marrow transplantation, hematopoietic stem and progenitor cells (HSPCs) respond to signals from the hematopoietic microenvironment by coordinately activating molecular pathways through Rho GTPases, including Rac. We have previously shown that deletion of Vav1, a hematopoietic-specific activator of Rac, compromises engraftment of transplanted adult HSPCs without affecting steady-state hematopoiesis in adult animals. Here, we show that Vav1^-/- fetal HSPCs can appropriately seed hematopoietic tissues during ontogeny but cannot engraft into lethally irradiated recipients. We demonstrate that the engraftment defect of Vav1^-/- HSPCs is abrogated in the absence of irradiation and demonstrate that Vav1 is critical for th

SUBMITTER: De Vita S 

PROVIDER: S-EPMC5823755 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature