Psychotherapy Alone and Combined With Medication as Treatments for Bipolar II Depression: A Randomized Controlled Trial.

ABSTRACT:

Objective

Bipolar II disorder (BP-II) is associated with marked morbidity and mortality. Quetiapine, the treatment with greatest evidence for efficacy in BP-II depression, is associated with metabolic burden. Psychotherapy, a treatment with few side effects, has not been systematically evaluated in BP-II. This study compared psychotherapy plus placebo to psychotherapy plus pharmacotherapy as treatments for BP-II depression.

Methods

From 2010 to 2015, unmedicated adults (n = 92) with DSM-IV-TR BP-II depression were randomly assigned to weekly sessions of Interpersonal and Social Rhythm Therapy (IPSRT) plus placebo or IPSRT plus quetiapine and followed for 20 weeks.

Results

For primary outcomes, IPSRT + quetiapine yielded significantly faster improvement on 17-item Hami

SUBMITTER: Swartz HA 

PROVIDER: S-EPMC5823786 | biostudies-literature | 2018 Mar/Apr

REPOSITORIES: biostudies-literature