HPV-transformed cells exhibit altered HMGB1-TLR4/MyD88-SARM1 signaling axis.

ABSTRACT: Cervical cancer is one of the leading causes of cancer death in women worldwide. Persistent infection with high-risk human papillomavirus (HPV) types is the main risk factor for the development of cervical cancer precursor lesions. HPV persistence and tumor development is usually characterized by innate immune system evasion. Alterations in Toll-like receptors (TLR) expression and activation may be important for the control of HPV infections and could play a role in the progression of lesions and tumors. In the present study, we analyzed the mRNA expression of 84 genes involved in TLR signaling pathways. We observed that 80% of the differentially expressed genes were downregulated in cervical cancer cell lines relative to normal keratinocytes. Major alterations were detected in genes codin

SUBMITTER: Morale MG 

PROVIDER: S-EPMC5823898 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature