Aberrant methylated key genes of methyl group metabolism within the molecular etiology of urothelial carcinogenesis.

ABSTRACT: Urothelial carcinoma (UC), the most common cancer of the urinary bladder causes severe morbidity and mortality, e.g. about 40.000 deaths in the EU annually, and incurs considerable costs for the health system due to the need for prolonged treatments and long-term monitoring. Extensive aberrant  DNA methylation is described to prevail in urothelial carcinoma and is thought to contribute to genetic instability, altered gene expression and tumor progression. However, it is unknown how this epigenetic alteration arises during carcinogenesis. Intact methyl group metabolism is required to ensure maintenance of cell-type specific methylomes and thereby genetic integrity and proper cellular function. Here, using two independent techniques for detecting DNA methylation, we observed DNA hypermethyla

SUBMITTER: Erichsen L 

PROVIDER: S-EPMC5823913 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature