Clinical and Immunological Features of Opsoclonus-Myoclonus Syndrome in the Era of Neuronal Cell Surface Antibodies.

ABSTRACT:

Importance

Most studies on opsoclonus-myoclonus syndrome (OMS) in adults are based on small case series before the era of neuronal cell surface antibody discovery.

Objective

To report the clinical and immunological features of idiopathic OMS (I-OMS) and paraneoplastic OMS (P-OMS), the occurrence of antibodies to cell surface antigens, and the discovery of a novel cell surface epitope.

Design, setting, and participants

Retrospective cohort study and laboratory investigations of 114 adult patients with OMS at a center for autoimmune neurological disorders done between January 2013 and September 2015.

Main outcomes and measures

Review of clinical records. Immunohistochemistry on rat brain and cultured neurons as well as cell-based assays were used to identify know

SUBMITTER: Armangue T 

PROVIDER: S-EPMC5823978 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature