Association Between SLC16A5 Genetic Variation and Cisplatin-Induced Ototoxic Effects in Adult Patients With Testicular Cancer.

ABSTRACT:

Importance

Cisplatin-induced ototoxic effects are an important complication that affects testicular cancer survivors as a consequence of treatment. The identification of genetic variants associated with this adverse drug reaction will further our mechanistic understanding of its development and potentially lead to strategies to prevent ototoxic effects.

Objective

To identify the genetic variants associated with cisplatin-induced ototoxic effects in adult testicular cancer patients.

Design, setting, and participants

This retrospective study was performed by the Canadian Pharmacogenomics Network for Drug Safety using patients recruited from 5 adult oncology treatment centers across Canada. Male patients who were 17 years or older, diagnosed with germ cell testicular can

SUBMITTER: Drogemoller BI 

PROVIDER: S-EPMC5824214 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature