Comparison of Survival Outcomes Among Human Papillomavirus-Negative cT1-2 N1-2b Patients With Oropharyngeal Squamous Cell Cancer Treated With Upfront Surgery vs Definitive Chemoradiation Therapy: An Observational Study.

ABSTRACT:

Importance

Human papillomavirus (HPV)-negative oropharyngeal squamous cell carcinoma (OPSCC) has shown resistance to conventional concurrent chemoradiation (CRT) therapy and carries a relatively poor prognosis in comparison with HPV-positive disease, with decreased locoregional control and overall survival (OS). In the present analysis, we examine whether upfront surgical resection improves overall survival in a large national sample.

Objective

To compare survival outcomes among patients with newly diagnosed cT1-2 N1-2b HPV-negative OPSCC when treated with primary surgical resection vs CRT.

Design, setting, and participants

This was an observational study of factors associated with primary treatment modality were identified using multivariable logistic regression. Ove

SUBMITTER: Kelly JR 

PROVIDER: S-EPMC5824218 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature