Association of Minimal Residual Disease With Clinical Outcome in Pediatric and Adult Acute Lymphoblastic Leukemia: A Meta-analysis.

ABSTRACT:

Importance

Minimal residual disease (MRD) refers to the presence of disease in cases deemed to be in complete remission by conventional pathologic analysis. Assessing the association of MRD status following induction therapy in patients with acute lymphoblastic leukemia (ALL) with relapse and mortality may improve the efficiency of clinical trials and accelerate drug development.

Objective

To quantify the relationships between event-free survival (EFS) and overall survival (OS) with MRD status in pediatric and adult ALL using publications of clinical trials and other databases.

Data sources

Clinical studies in ALL identified via searches of PubMed, MEDLINE, and clinicaltrials.gov.

Study selection

Our search and study screening process adhered to the PRISMA Guid

SUBMITTER: Berry DA 

PROVIDER: S-EPMC5824235 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature