Baseline Surveillance in Li-Fraumeni Syndrome Using Whole-Body Magnetic Resonance Imaging: A Meta-analysis.

ABSTRACT:

Importance

Guidelines for clinical management in Li-Fraumeni syndrome, a multiple-organ cancer predisposition condition, are limited. Whole-body magnetic resonance imaging (WBMRI) may play a role in surveillance of this high-risk population.

Objective

To assess the clinical utility of WBMRI in germline TP53 mutation carriers at baseline.

Data sources

Clinical and research surveillance cohorts were identified through the Li-Fraumeni Exploration Research Consortium.

Study selection

Cohorts that incorporated WBMRI for individuals with germline TP53 mutations from January 1, 2004, through October 1, 2016, were included.

Data extraction and synthesis

Data were extracted by investigators from each cohort independently and synthesized by 2 investigators. Random

SUBMITTER: Ballinger ML 

PROVIDER: S-EPMC5824277 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature