Clinical and Radiologic Responses to Cladribine for the Treatment of Erdheim-Chester Disease.

ABSTRACT:

Importance

While cladribine is best known for the treatment of hairy cell leukemia and other lymphoid cancers, it also has activity against myeloid neoplasms, such as Erdheim-Chester disease (ECD).

Objective

To assess the efficacy of cladribine (2-chloro-2'-deoxyadenosine) in the treatment of ECD.

Design, setting, and participants

This study was a single-institution retrospective medical record review from January 1, 1998, to April 6, 2016, at a tertiary academic medical center. In all eligible cases, the diagnosis of ECD was made using clinical criteria in conjunction with histopathologic findings.

Exposure

Cladribine therapy in first-line treatment or later.

Main outcomes and measures

Two response criteria were used, clinical and radiological. For clin

SUBMITTER: Goyal G 

PROVIDER: S-EPMC5824289 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature