ALDH2 gene G487A polymorphism and coronary artery disease: a meta-analysis including 5644 participants.

ABSTRACT: Several studies indicate the mitochondrial Aldehyde Dehydrogenase-2 (ALDH2) gene G487A polymorphism may be correlated with coronary artery disease (CAD) susceptibility, but a clear consensus has yet to be reached. To elucidate the relationship between the ALDH2 gene G487A polymorphism and CAD within the Chinese population, a meta-analysis of 5644 subjects from nine individual studies was performed. Pooled odds ratios (ORs) and their corresponding 95% confidence intervals were assessed using random or fixed-effect models depending the heterogeneity existence or not. Our meta-analysis found a significant association between ALDH2 gene G487A polymorphism and CAD in the Chinese population under allele (OR: 1.830, 95% CI: 1.560-2.140, P = 1.36 × 10^-13 ), recessive (OR: 1.920, 95% CI:

SUBMITTER: Li YY 

PROVIDER: S-EPMC5824379 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature