Transcriptional profiles of different states of cancer stem cells in triple-negative breast cancer.

ABSTRACT: Breast cancer stem cells (BCSCs) are thought to be responsible for tumor initiation, metastasis and relapse. Our group and others have described markers useful in isolating BCSCs just as aldehyde dehydrogenase positive (ALDH⁺) or CD24^-CD44⁺. In fact, cells which simultaneously express both sets of markers have the highest tumor initiating capacity. Although the transcriptomic profile of cells expressing each BCSC marker alone has been reported, the profile of the most tumorigenic population expressing both sets of markers has not. Here we used the biomarker combination of ALDH and CD24/CD44 to sort four populations isolated from triple-negative breast cancer (TNBC) patient-derived xenografts, and performed whole-transcriptome sequencing on each population.

SUBMITTER: Liu M 

PROVIDER: S-EPMC5824475 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature