The NAD⁺-Dependent Family of Sirtuins in Cerebral Ischemia and Preconditioning.

ABSTRACT:

Significance

Sirtuins are an evolutionarily conserved family of NAD⁺-dependent lysine deacylases and ADP ribosylases. Their requirement for NAD⁺ as a cosubstrate allows them to act as metabolic sensors that couple changes in the energy status of the cell to changes in cellular physiological processes. NAD⁺ levels are affected by several NAD⁺-producing and NAD⁺-consuming pathways as well as by cellular respiration. Thus their intracellular levels are highly dynamic and are misregulated in a spectrum of metabolic disorders including cerebral ischemia. This, in turn, compromises several NAD⁺-dependent processes that may ultimately lead to cell death. Recent Advances: A number of efforts have been made to replenish NAD

SUBMITTER: Khoury N 

PROVIDER: S-EPMC5824497 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature