A maximum likelihood algorithm for reconstructing 3D structures of human chromosomes from chromosomal contact data.

ABSTRACT:

Background

The development of chromosomal conformation capture techniques, particularly, the Hi-C technique, has made the analysis and study of the spatial conformation of a genome an important topic in bioinformatics and computational biology. Aided by high-throughput next generation sequencing techniques, the Hi-C technique can generate genome-wide, large-scale intra- and inter-chromosomal interaction data capable of describing in details the spatial interactions within a genome. These data can be used to reconstruct 3D structures of chromosomes that can be used to study DNA replication, gene regulation, genome interaction, genome folding, and genome function.

Results

Here, we introduce a maximum likelihood algorithm called 3DMax to construct the 3D structure of a chromoso

SUBMITTER: Oluwadare O 

PROVIDER: S-EPMC5824572 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature