Whole genome duplications have provided teleosts with many roads to peptide loaded MHC class I molecules.

ABSTRACT:

Background

In sharks, chickens, rats, frogs, medaka and zebrafish there is haplotypic variation in MHC class I and closely linked genes involved in antigen processing, peptide translocation and peptide loading. At least in chicken, such MHCIa haplotypes of MHCIa, TAP2 and Tapasin are shown to influence the repertoire of pathogen epitopes being presented to CD8+ T-cells with subsequent effect on cell-mediated immune responses.

Results

Examining MHCI haplotype variation in Atlantic salmon using transcriptome and genome resources we found little evidence for polymorphism in antigen processing genes closely linked to the classical MHCIa genes. Looking at other genes involved in MHCI assembly and antigen processing we found retention of functional gene duplicates originating from

SUBMITTER: Grimholt U 

PROVIDER: S-EPMC5824609 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature