The P-type ATPase inhibiting potential of polyoxotungstates.

ABSTRACT: Polyoxometalates (POMs) are transition metal complexes that exhibit a broad diversity of structures and properties rendering them promising for biological purposes. POMs are able to inhibit a series of biologically important enzymes, including phosphatases, and thus are able to affect many biochemical processes. In the present study, we analyzed and compared the inhibitory effects of nine different polyoxotungstates (POTs) on two P-type ATPases, Ca²⁺-ATPase from skeletal muscle and Na⁺/K⁺-ATPase from basal membrane of skin epithelia. For Ca²⁺-ATPase inhibition, an in vitro study was performed and the strongest inhibitors were determined to be the large heteropolytungstate K₉(C₂H₈N)₅[H₁₀Se

SUBMITTER: Gumerova N 

PROVIDER: S-EPMC5824666 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature