⁴⁷Sc as useful β^--emitter for the radiotheragnostic paradigm: a comparative study of feasible production routes.

ABSTRACT:

Background

Radiotheragnostics makes use of the same molecular targeting vectors, labeled either with a diagnostic or therapeutic radionuclide, ideally of the same chemical element. The matched pair of scandium radionuclides, ⁴⁴Sc and ⁴⁷Sc, satisfies the desired physical aspects for PET imaging and radionuclide therapy, respectively. While the production and application of ⁴⁴Sc was extensively studied, ⁴⁷Sc is still in its infancy. The aim of the present study was, therefore, to investigate and compare two different methods of ⁴⁷Sc production, based on the neutron irradiation of enriched ⁴⁶Ca and ⁴⁷Ti targets, respectively.

Methods

⁴⁷Sc was produced by thermal neutron irradiation of enrich

SUBMITTER: Domnanich KA 

PROVIDER: S-EPMC5824697 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature