Production and separation of ⁴³Sc for radiopharmaceutical purposes.

ABSTRACT:

Background

The favorable decay properties of ⁴³Sc and ⁴⁴Sc for PET make them promising candidates for future applications in nuclear medicine. An advantage ⁴³Sc (T_1/2 = 3.89 h, Eβ⁺_av = 476 keV [88%]) exhibits over ⁴⁴Sc, however, is the absence of co-emitted high energy γ-rays. While the production and application of ⁴⁴Sc has been comprehensively discussed, research concerning ⁴³Sc is still in its infancy. This study aimed at developing two different production routes for ⁴³Sc, based on proton irradiation of enriched ⁴⁶Ti and ⁴³Ca target material.

Results

⁴³Sc was produced via the ⁴⁶Ti(p,α)⁴³Sc and ^43<

SUBMITTER: Domnanich KA 

PROVIDER: S-EPMC5824704 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature