A common deletion in the haptoglobin gene associated with blood cholesterol levels among Chinese women.

ABSTRACT: Haptoglobin (HP) protein plays a critical role in binding and removing free hemoglobin from blood. A deletion in the HP gene affects the protein structure and function. A recent study developed a novel method to impute this variant and discovered significant association of this variant with low-density lipoprotein (LDL) and total cholesterol levels among European descendants. In the present study, we investigated this variant among 3608 Chinese women. Consistent with findings from Europeans, we found significant associations between the deletion with lower cholesterol levels; women homozygous for the deletion allele (HP1-HP1), had a lower level of total cholesterol (-4.24 mg dl^-1, P=0.02) and LDL cholesterol (-3.43 mg dl^-1, P=0.03) than those not carrying the deletion

SUBMITTER: Zheng NS 

PROVIDER: S-EPMC5824713 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature